That might not be the only play to consider. The official play-by-play shows a penalty for defensive pass interference wiping out an apparent completed pass to 49ers receiver Mario Manningham during the 49ers' opening drive. It is unclear, however, whether the 49ers accepted the penalty. The flag was thrown on a second-and-4 play, so the 49ers would have gained nothing by accepting the penalty. If the 49ers did not accept the penalty, the league could conceivably change the play from 7-yard penalty to 7-yard completed pass. The NFL made a similar change in Week 2 last season.