SANTA CLARA — The 49ers will have at least four players on their 53-man roster unavailable for the NFC West matchup against the Seattle Seahawks on Sunday.Fullback Kyle Juszczyk is expected to sit out multiple weeks due to a right knee injury, while starting safety Marques Sigle is expected to miss at least a month with a high-ankle sprain.
Defensive linemen Nick Bosa (knee, calf) and James Thompson Jr. (ankle) will both miss their third consecutive games with their injuries.
In addition, nickel back Upton Stout is dealing with a sprained AC joint in his shoulder. He begins the practice week with his status unclear for the 49ers’ Week 5 game against last season’s Super Bowl champions.
Stout was not scheduled to practice on Wednesday, 49ers coach Kyle Shanahan said.
Juszczyk sustained a right knee hyperextension and bone bruise in the 49ers’ 24-14 victory over the Denver Broncos on Sunday. He was injured when Broncos safety Jahdae Barron struck him low just as Juszczyk was turning upfield after catching a pass from quarterback Brock Purdy.
The 49ers expect to get one key player...
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