Wide receivers Deebo Samuel and Jauan Jennings have been ailing. Neither has practiced this week. Samuel is dealing with rib and knee injuries, while Jennings is working through a shin injury.
Both receivers participated in the 49ers' walk-through on Thursday but exited as their teammates started preparing for practice. Samuel left for the weight room and wasn't seen again by reporters. Jennings was seen getting some work on a side field.
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The good news is that wide receiver Brandon Aiyuk is trending towards playing. He has been limited in practices this week due to a shoulder injury but finally shed his blue no-contact jersey during Thursday's session. Aiyuk was among the 49ers' inactive players against the New York Giants last week.
Head coach Kyle Shanahan joined KNBR on Thursday for his weekly radio interview and provided an update on his ailing receivers. It sounds like neither Samuel nor Jennings being available for Sunday's game against the Arizona Cardinals is a real possibility.
"Aiyuk was out there at practice today, but Deebo and Jauan weren't able to practice, and they'll be questionable for the game," Shanahan said on the "Tolbert and Copes" show. "I know we don't do that yet, but we'll see how they go tomorrow. But hopefully, they can get out tomorrow and give them a chance for Sunday."
The 49ers will release official game statuses after Friday's practice.
You can listen to the entire conversation with Shanahan below.