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Isaac Guerendo, RB #31

Height: 6-0

Weight: 221

Born: 6/28/2000

College: Louisville

Experience: 2 seasons

2025 Cap: $1,136,132

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49ers Webzone › Forums
Big, fast and a really good receiver out of the backfield. He compares favorably to Isaiah Pacheco of the Chiefs. This will be the "gotta give McCaffrey a
Updated Oct 26 at 12:58 PM • Share
From the Web › NBCS Bay Area
SANTA CLARA — On the first play of 11-on-11 work during 49ers practice on Tuesday, running back Isaac Guerendo took a handoff from quarterback Brock Purdy.On the...
Posted Aug 19 at 3:20 PM • Share
From the Web › Pro Football Talk
The 49ers are going to be down a couple of players for the near future. Head coach Kyle Shanahan told reporters at a Monday press conference that running back...
Posted Aug 4 at 1:00 PM • Share
49ers Webzone › Articles
49ers guard Dominick Puni praises Christian McCaffrey's leadership and predicts that his running back duo with Isaac Guerendo will be a 'crazy one-two punch.'
Posted Aug 2 at 9:01 AM • Share
From the Web › SI.com
Deebo Samuel is gone and Brandon Aiyuk might never be the same after tearing his ACL, MCL and meniscus. Which means the 49ers need someone new to step up...
Posted Jul 6 at 1:00 PM • Share
49ers Webzone › Articles
Bleacher Report ranks the 49ers' Christian McCaffrey and Isaac Guerendo as a top-tier running back duo. Can the 49ers dominate on the ground in 2025?
Posted Jun 9 at 8:50 AM • Share
From the Web › SI.com
Just a year ago, the 49ers traded up to take Isaac Guerendo in Round 4. Now, he might not make their 53-man roster this year.
Posted May 4 at 3:00 PM • Share
49ers Webzone › Articles
PFSN reveals surprise 49ers trade candidate: Could Isaac Guerendo be on the move after San Francisco's crowded backfield additions this offseason?
Posted May 3 at 9:17 AM • Share
49ers Webzone › Articles
Isaac Guerendo earns praise from Christian McCaffrey after a strong rookie year, setting the stage for a bigger role in the 49ers' backfield in 2025.
Posted Apr 23 at 12:02 PM • Share
From the Web › 49ers.com
The San Francisco 49ers are scheduled to make two selections in the fourth round of the 2025 NFL Draft. Take a look at the team's history of success in the fourth...
Posted Apr 17 at 10:40 AM • Share
From the Web › SI.com
One of the 49ers' most intriguing rookies last season was Isaac Guerendo. He didn't play a ton -- just 222 offensive snaps to be exact. And that's because he a backup...
Posted Apr 12 at 3:00 PM • Share
49ers Webzone › Articles
Kyle Shanahan affirms confidence in Christian McCaffrey and Isaac Guerendo but keeps the door open for RB depth in the NFL Draft after trading Jordan Mason.
Posted Apr 1 at 10:50 AM • Share
49ers Webzone › Articles
San Francisco 49ers rookie RB Isaac Guerendo suffered MCL and ankle sprains against the Arizona Cardinals, avoiding an ACL injury.
Posted Jan 6 at 5:13 PM • Share
49ers Webzone › Articles
Isaac Guerendo shares an encouraging update after avoiding major injury, reassuring 49ers fans he will "be back better than ever."
Posted Jan 6 at 1:04 PM • Share
49ers Webzone › Articles
The 49ers fear RB Isaac Guerendo suffered an MCL injury against the Cardinals in Week 18. Kyle Shanahan provides several injury updates from the game.
Posted Jan 5 at 5:14 PM • Share
From the Web › Pro Football Talk
The 49ers lost another running back Sunday. Isaac Guerendo was carted off the field with injuries to his left knee and ankle. The team ruled out his return...
Posted Jan 5 at 2:20 PM • Share
49ers Webzone › Articles
Get the latest 49ers injury updates as they play the Cardinals, including news on RB Isaac Guerendo.
Posted Jan 5 at 1:37 PM • Share
From the Web › Niners Wire
San Francisco 49ers RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17.
Posted Dec 28 '24 a 10:20 PM • Share
From the Web › Pro Football Talk
The 49ers will have running back Isaac Guerendo for Monday Night Football. Guerendo, who missed last week's game with a hamstring injury, does not have an injury...
Posted Dec 28 '24 a 3:00 PM • Share
49ers Webzone › Articles
San Francisco 49ers running back Isaac Guerendo, sidelined for last Sunday's game against the Miami Dolphins due to hamstring and foot injuries, has been limited in...
Posted Dec 28 '24 a 12:11 PM • Share
From the Web › Niners Wire
Hey here's some good news!
Posted Dec 26 '24 a 3:40 PM • Share
From the Web › Niners Wire
The San Francisco 49ers will have to navigate life on their 4th-string RB against the Miami Dolphins.
Posted Dec 21 '24 a 10:40 AM • Share
From the Web › Pro Football Talk
49ers head coach Kyle Shanahan called running back Isaac Guerendo a long shot to play against the Dolphins earlier this week and he moved to no shot on Friday. Guerendo...
Posted Dec 20 '24 a 2:40 PM • Share
From the Web › Pro Football Talk
Reporting emerged earlier on Thursday noting that 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the Dolphins due to a hamstring injury...
Posted Dec 19 '24 a 4:40 PM • Share
49ers Webzone › Articles
On Thursday, ESPN insider Adam Schefter reported that San Francisco 49ers rookie running back Isaac Guerendo is unlikely to play against the Miami Dolphins on Sunday...
Posted Dec 19 '24 a 3:43 PM • Share
From the Web › SI.com
The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because rookie running back Isaac Guerendo is likely to...
Posted Dec 19 '24 a 11:40 AM • Share
From the Web › Pro Football Talk
The 49ers have gotten used to being shorthanded at running back this season and it looks like they'll be down another one in Miami on Sunday. Adam Schefter of ESPN...
Posted Dec 19 '24 a 9:40 AM • Share
49ers Webzone › Articles
San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against the Los Angeles...
Posted Dec 19 '24 a 9:21 AM • Share
From the Web › Niners Wire
The San Francisco 49ers will have a fourth different starting RB against the Miami Dolphins.
Posted Dec 19 '24 a 9:20 AM • Share
49ers Webzone › Articles
San Francisco 49ers head coach Kyle Shanahan provided key injury updates ahead of Wednesday's practice as the team prepares for its Week 16 road game against the Miami...
Posted Dec 18 '24 a 12:09 PM • Share
From the Web › Pro Football Talk
The 49ers will have defensive lineman Nick Bosa, linebacker Dre Greenlaw and running back Isaac Guerendo for Thursday Night Football. All three are active after...
Posted Dec 12 '24 a 4:20 PM • Share
From the Web › NFL.com
Running back Isaac Guerendo is officially active for the the 49ers' pivotal "Thursday Night Football" game against the Los Angeles Rams despite dealing...
Posted Dec 12 '24 a 4:00 PM • Share
From the Web › NFL.com
On "Good Morning Football", NFL Network Insider Mike Garafolo elaborates on the status of San Francisco 49ers running back Isaac Guerendo ahead of tonight's matchup...
Posted Dec 12 '24 a 9:03 AM • Share
From the Web › SI.com
Rookie running back Isaac Guerendo is expected to play through a foot sprain tonight against the Los Angeles Rams. Guerendo is the 49ers' third starting running back of...
Posted Dec 12 '24 a 7:40 AM • Share
49ers Webzone › Articles
According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday night's game against the Los Angeles Rams...
Posted Dec 12 '24 a 7:00 AM • Share
From the Web › Pro Football Talk
49ers running back Isaac Guerendo became the team's starter last week and the rookie scored two touchdowns against the Bears, but his day ended on a down note. Guerendo...
Posted Dec 12 '24 a 5:00 AM • Share
From the Web › 49ers.com
The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup vs. the Los Angeles Rams.
Posted Dec 11 '24 a 2:40 PM • Share
From the Web › Niners Wire
All the latest updates and news on 49ers' injury report ahead of a Week 15 game vs. the Rams.
Posted Dec 11 '24 a 1:40 PM • Share
49ers Webzone › Articles
The San Francisco 49ers will hold their lone full practice of a shortened week on Tuesday evening as they prepare for Thursday night's pivotal NFC West clash against the...
Posted Dec 10 '24 a 2:44 PM • Share
From the Web › Pro Football Talk
49ers head coach Kyle Shanahan shared his team's pre-practice injury report at a Tuesday press conference and it was the same as Monday's estimated one, so several key...
Posted Dec 10 '24 a 2:20 PM • Share
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