The 49ers (6-4) fell behind 21-0 early, yielded six touchdowns and produced no takeaways in a 42-26 loss to the Rams (7-2)
Rams 42, 49ers 26: Injury-thinned defense yields most points this season
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Recap: Bad start and a big day from Matthew Stafford bury 49ers in 42-26 loss to Rams
By Kirk Larrabee
Nov 9, 2025
The realities of an injury-depleted roster were on display for the San Francisco 49ers on Sunday, and they weren't pretty.
The 49ers faced a Los Angeles Rams team at Levi's Stadium in Santa Clara on Sunday that it knocked off in an overtime instant classic in Week 5, but...
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