The San Francisco 49ers and Seattle Seahawks will meet on Sunday at Lumen Field. Here's how the odds look heading into the matchup.
49ers vs. Seahawks odds: San Francisco open as one-score favorites over Seattle
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49ers vs. Seahawks in Week 1: How to watch, stream, and listen, plus odds
By Site Staff
Sep 3, 2025
The San Francisco 49ers open the 2025 regular season on the road against the Seattle Seahawks at Lumen Field. This matchup marks the 55th all-time meeting between the two teams and only the third time in series history that they have faced off in Week 1. The Niners will be...
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