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- September 26, 2021; 5:20 pm (PT)
- 49ers -3; O/U 50.5
- Venue: Levi's Stadium
Injury Report:
49ers
Out: DT Kevin Givens (ankle), RB JaMycal Hasty (ankle)
Doubtful: RB Elijah Mitchell (shoulder)
Packers
Doubtful: G Elgton Jenkins (ankle)
Questionable: TE Dominique Dafney (hip)