49ers’ 2022 schedule among the toughest in strength-of-schedule rankings

The NFL will announce the entire 2022 slate of matchups on Thursday night. That's when we'll learn the dates and times for all 272 regular-season games. However, we've known the opponents for a while now. If the San Francisco 49ers are to return to the playoffs for the third time in four years, it won't be an easy road.

San Francisco's upcoming opponents went 154-135 in 2021. The team's schedule will include seven matchups against opponents coming off a playoff appearance (Rams twice, Cardinals twice, Chiefs, Buccaneers, Raiders). Those opponents had a total winning percentage of .533 in 2021, which is good enough to tie with the Kansas City Chiefs as the fifth-toughest schedule based on the opponents' winning percentage (strength of schedule).

Only the defending Super Bowl champion Los Angeles Rams (.567), the Arizona Cardinals (.543), the Cincinnati Bengals (.536), and the Tampa Bay Buccaneers (.535) own tougher strength of schedules.

San Francisco will likely embark on their 2022 campaign with second-year quarterback Trey Lance at the helm of the offense. Veteran Jimmy Garoppolo is expected to be traded after he recovers from his offseason shoulder surgery—assuming trade partners are still out there. That could make things more challenging for the team, which is coming off an NFC title appearance.

The hope is that Lance is ready for the responsibility, and the 49ers have publicly stated that they believe he is.

Below is the ranking of each team's strength of schedule for the upcoming season.

Rank	Team	Opponent's 2021 record	Opponents' 2021 win %
1	Rams	164-125-0	.567
2	Cardinals	157-132-0	.543
3	Bengals	154-133-2	.536
4	Buccaneers	154-134-1	.535
T-5	49ers	154-135-0	.533
T-5	Chiefs	154-135-0	.533
T-7	Raiders	152-136-1	.528
T-7	Saints	152-136-1	.528
9	Falcons	151-137-1	.524
10	Chargers	150-139-0	.519
11	Seahawks	149-139-1	.517
T-12	Steelers	148-141-0	.512
T-12	Panthers	147-140-2	.512
T-12	Bills	147-140-2	.512
15	Broncos	147-142-0	.509
16	Patriots	143-144-2	.498
T-17	Jets	142-145-2	.495
T-17	Browns	142-145-2	.495
19	Texans	141-148-0	.488
20	Vikings	139-148-2	.484
21	Dolphins	138-149-2	.481
22	Packers	137-150-2	.478
23	Ravens	136-151-2	.474
T-24	Bears	135-152-2	.471
T-24	Titans	136-153-0	.471
T-26	Jaguars	135-153-1	.469
T-26	Colts	135-153-1	.469
28	Lions	135-154-0	.467
29	Giants	134-154-1	.465
30	Eagles	133-154-2	.464
T-31	Commanders	133-155-1	.462
T-31	Cowboys	133-155-1	.462

49ers' 2022 opponents

HOME (9 games)

• Arizona Cardinals
• Kansas City Chiefs
• Los Angeles Chargers
• Los Angeles Rams
• Miami Dolphins
• New Orleans Saints
• Seattle Seahawks
• Tampa Bay Buccaneers
• Washington Commanders

AWAY (8 games)

• Arizona Cardinals
• Atlanta Falcons
• Carolina Panthers
• Chicago Bears
• Denver Broncos
• Los Angeles Rams
• Las Vegas Raiders
• Seattle Seahawks