Tonight, the New York Giants (2-2) will host the San Francisco 49ers (1-3) at MetLife Stadium in East Rutherford, New Jersey. This marks San Francisco's lone game against an NFC East opponent this season.

The 49ers are coming off of a 17-3 defeat against the Green Bay Packers. The Giants are coming off of a 24-10 victory against the Buffalo Bills.

The 49ers have lost their last three games. In those losses, they have been outscored 107-28. The 49ers, who are the NFL's lowest-scoring offense, have not scored a touchdown in the past six quarters of play.

QB Colin Kaepernick, playing behind one of the worst offensive lines in the league, has a 67.7 passer rating on the season and a 25.7 rating over the last two weeks. That includes a career low 16.7 rating that he suffered during week three against the the Arizona Cardinals.

Of the quarterbacks that have at least 60 passes, Kaepernick ranks second to last through four games according to Football Outsiders.

The 49ers have had one of the toughest schedules in the NFL through four weeks of play, and it will not be getting any easier. They hope to avoid their worst road losing streak in more than five years. The Giants are looking to win their third straight game after dropping their first two. QB Eli Manning has completed 62.9% of his passes for 976 yards, seven touchdowns and only one interception.

LB Ahmad Brooks will miss the game due to a death in the family. TE Vernon Davis will miss his second straight game with a knee injury. He did not play in last week's loss to the Packers. WR Quinton Patton (concussion) and T Joe Staley (knee) are questionable.

G Andrew Tiller was promoted from the practice squad on Saturday. To make room for him, the 49ers released CB Shareece Wright, who was vocal about the team's refusal to play him and wanted out of San Francisco.

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The 49ers inactives against the Giants are WR DeAndrew White, RB Mike Davis, LB Gerald Hodges, LB Ahmad Brooks, OL Ian Silberman, NT Mike Purcell, and TE Vernon Davis. That means both Tiller and Staley will suit up for the 49ers.

Kickoff: Sunday, October 11 at 5:30 PM PT

Television: The game will be televised nationally on NBC

Bay Area Radio: KGO 810 & The Bone 107.7 (Other radio affiliates)

Spanish Radio: KTRB 860

Australian Radio: Triple M

All-Time Matchup: Series is tied 19-19

Last Meeting: 11/16/14, 49ers win 16-10, at NYG

Current Streak: Won 1

Betting: The Giants are 6.5 point favorites.

NFL Fan Picks: 75% pick the Giants to win according to Yahoo! Sports

49ers Fan Picks: Within our Pick 'em Contest, 58% believe the Giants will win

49ers Schedule: View full schedule

Giants News: Giants news at

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Injury Report

49ers LB Ahmad Brooks Not injury related Out
49ers TE Vernon Davis Knee Out
49ers WR Quinton Patton Concussion Questionable
49ers T Joe Staley Knee Questionable
49ers G Alex Boone Shoulder, ankle Probable
49ers LB NaVorro Bowman Not injury related Probable
49ers S L.J. McCray Knee Probable
49ers TE Vance McDonald Chest Probable
Giants DE Robert Ayers Jr. Hamstring Out
Giants WR Victor Cruz Calf Out
Giants LB Devon Kennard Hamstring Out
Giants DE George Selvie Calf Out
Giants LB Jonathan Casillas Calf Questionable
Giants CB Jayron Hosley Concussion Questionable
Giants CB Trumaine McBride Groin Questionable
Giants TE Jerome Cunningham Knee Probable

Game Averages (Rank)

49ers Giants
12.0 (32nd)
Offense Pts
25.5 (9th)
289.0 (31st)
Offense Yds
335.8 (21st)
158.8 (32nd)
Offense Pass
242.8 (19th)
130.2 (5th)
Offense Rush
93.0 (24th)
27.5 (28th)
Defense Pts Allowed
20.5 (11th)
377.2 (23rd)
Defense Yds Allowed
386.0 (26th)
263.2 (21st)
Defense Pass Allowed
316.2 (32nd)
114.0 (21st)
Defense Rush Allowed
69.8 (1st)

Game Articles

Articles to be added as they become available.

49ers OC Geep Chryst: 'We made some adjustments we feel good about'
The Mercury News

Preview: San Francisco 49ers at New York Giants
The Mercury News

CBS Sports: Victor Cruz Sidelined Again

49ers' Ward: Beckham going to fight, but 'not as shifty as Cobb'
CSN Bay Area

NaVorro Bowman says 49ers in an 'important spot' heading into New York's big stage
The Mercury News

What to watch for Week 5
Press Democrat

No place to hide: Struggling Kaepernick to go under national spotlight
Sacramento Bee

Behind enemy lines: get to know Big Blue
Niners Digest

49ers game at New York Giants at a glance
Sacramento Bee

Week 5 Preview: San Francisco 49ers v. New York Giants
Niner Fans

Pregame: 49ers draft picks must fill Ahmad Brooks' void; TE Vernon Davis, LB Hodges among inactives
The Mercury News

49ers pregame: Staley to start; Andrew Tiller, Brandon Thomas active
Sacramento Bee