The San Francisco 49ers will travel to face the Houston Texans at Reliant Stadium in Houston, Texas.
The 49ers are coming off of a 17-6 preseason win over the Minnesota Vikings while the Texans are coming off of a 26-13 win over the Carolina Panthers.
The game kicks off at 5:00 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised locally in the Bay Area on CBS-5.
Within Sportstacular, a popular mobile phone scores application, 73% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
Who are you most looking forward to seeing in this preseason game? Leave your comments below.