The 49ers were down 17-13 with Colin Kaepernick making his first start since November 2015.
Bills stampede over miserable 49ers, 45-16
The above videos are auto-populated by an affiliate.
Follow us on:
The above link leads to an external page. 49ers Webzone has no control over its contents.
Similar Article Found
Recap: 49ers have no answer for LeSean McCoy, Bills in 45-16 loss
Recap: 49ers have no answer for LeSean McCoy, Bills in 45-16 loss
By Site Staff
Oct 16, 2016
Read Next
49ers officially announce 2026 NFL Mexico City game at Estadio Banorte
49ers officially announce 2026 NFL Mexico City game at Estadio Banorte
By Site Staff
Feb 18
The San Francisco 49ers have officially announced they will play a regular-season game in Mexico City during the 2026 NFL season, continuing the league's international expansion efforts.
News of the 49ers serving as the designated home team for the international matchup was...
Where 49ers RB Christian McCaffrey landed in PFF's top 101 players of 2025
Where 49ers RB Christian McCaffrey landed in PFF's top 101 players of 2025
By David Bonilla
Feb 18
After injuries limited him to just four games in 2024, San Francisco 49ers running back Christian McCaffrey fell off Pro Football Focus' (PFF) Top 101 list. He ensured the absence was short-lived.
McCaffrey rebounded in 2025 with a dominant, full 17-game campaign, totaling...
49ers report: NFL execs expect high trade price for Mac Jones
49ers report: NFL execs expect high trade price for Mac Jones
By David Bonilla
Feb 18
The San Francisco 49ers have made their stance on Mac Jones clear: they would prefer to keep the veteran quarterback on the roster in 2026. Still, that hasn't quieted speculation about his NFL future.
San Francisco has consistently signaled a willingness to listen to at least...
49ers expected to break NFL travel record with grueling 2026 schedule
49ers expected to break NFL travel record with grueling 2026 schedule
By David Bonilla
Feb 18
The NFL has officially announced that the San Francisco 49ers will host a regular-season game in Mexico City during the 2026 NFL season, with the matchup expected to take place in Week 13 or 14 at Estadio Banorte.
That won't be the only international trip on the 49ers'...
Latest
- 49ers fans won't like ESPN's ideal landing spot for Jauan Jennings
- 49ers reportedly targeting Louisville receiver amid NFL Combine buzz
- 49ers NFL Combine Watch: Defensive Linemen and Linebackers Risers and Fallers
- Report: 49ers special teams contributor expected to draw interest from others
- NFL announces 2026 salary cap set at $301.2 million
Trending News
-
49ers Webzone • Feb 26
-
49ers Webzone • Feb 26
-
49ers Webzone • Feb 26
-
49ers Webzone • Feb 26
-
Niners Wire • Feb 26
-
49ers Webzone • 7 hrs