The 49ers will have tight end George Kittle for today's game against the Seahawks after coming down with an illness.
Kittle is not on the team's inactive list, as expected.
Defensive end Mykel Williams will make his 2026 debut after working his way back from a knee injury that ended his 2025 season. Cornerback Upton Stout will also play after being listed as questionable with a shoulder injury.
The 49ers already had ruled out defensive lineman Nick Bosa (knee/calf), defensive lineman James Thompson Jr. (ankle), fullback Kyle Juszczyk (knee and safety Marques Sigle (ankle). Linebacker Tatum Bethune, offensive lineman Enrique Cruz and quarterback Kurtis Rourke are the other inactives.
The Seahawks' inactives are quarterback Jalen Milroe, running back Robert Henry Jr., linebacker Chazz Surratt (calf), wide receiver Montorie Foster Jr. and tight end Nick Kallerup. Milroe will serve as the emergency third quarterback.
More info on: Tatum Bethune, Nick Bosa, Enrique Cruz, Kyle Juszczyk, George Kittle, Kurtis Rourke, Marques Sigle, Upton Stout, James Thompson, Mykel Williams