Following the 49ers’ final preseason game on Thursday night in Las Vegas, the real work began for coach Kyle Shanahan and general manager John Lynch.The 49ers have an abundance of injury questions entering Week 1, but only wide receiver Ricky Pearsall was lost for the 2026 NFL season this summer.
All NFL teams must reduce their rosters from 90 players to the 53-man limit by Sunday at 3 p.m.
And the medical reports will determine how the 49ers piece it together ahead of their trip to Melbourne, Australia, to face the Los Angeles Rams on Thursday, Sept. 10.
“That’s why you want as long as possible,” Shanahan said. “They’re moving it up this year on Sunday with us leaving for Australia so soon. So it just makes it a little bit harder to guess where those guys are going to be.
“Most of our guys, besides Ricky, are going to be all right. How good are they going to be Week 1? How good are they going to be Week 2? Those are things we’ve got to balance out.”
And that is why projecting the 49ers’ initial 53-man roster becomes so difficult.
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