Breaking down 49ers’ substantial 2025 NFL schedule rest advantage vs. opponents

The 2025 NFL schedule is set up much more favorably for the 49ers compared to the past few seasons.San Francisco has an easier schedule by most metrics, including playing teams that finished last in their respective divisions. But maybe more importantly, the 49ers surprisingly do not play any teams coming off a bye week. Not one.In 2024, the 49ers faced four teams coming off bye weeks, including when they hosted the Kansas City Chiefs and the Dallas Cowboys in back-to-back weeks. Later, they welcomed a well-rested Seattle Seahawks team in Week 11 and then traveled to Buffalo two weeks after the Bills had a week off.If that wasn't enough to tip the scales, the 49ers last season also matched up with opponents who had a mini-bye due to a Thursday night game the week prior — New England in Week 4 and the Chicago Bears in Week 14.Of those six games, the 49ers won three, only securing victories over the teams that finished the season with losing records (Patriots, Cowboys, Bears). Now in 2025, without a significant rest disadvantage, the 49ers should be favored to win in many of their matchups.Here's a look at the 49ers' 2025 schedule and what their opponents will be facing the week...