The 49ers will play in Mexico this November for their first visit since 2005, and they again will be hosted by the Arizona Cardinals.
49ers will return to Mexico City to face Cardinals in 2022
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49ers to face Cardinals in Mexico City on November 21
By David Bonilla
May 4, 2022
The San Francisco 49ers will take part in an international game in 2022. They will be the designated road team, traveling to face the "home team" Arizona Cardinals at Estadio Azteca in Mexico City on November 21 (Week 11)—a primetime matchup on ESPN's Monday Night...
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