Highlighting significant notes, primetime matchups, preseason contests, the strength of the 49ers slate and other oddities in San Francisco's 2021 schedule.
9 Observations from the 49ers 2021 NFL Schedule
Published May 12, 2021 at 5:00 PM
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Complete 2021 San Francisco 49ers Schedule Revealed
By David Bonilla
May 12, 2021
The NFL revealed its complete 272-game 2021 regular-season schedule on Wednesday at 5:00 p.m. PT.
The San Francisco 49ers open the season with back-to-back road games against the Detroit Lions at Ford Field and then the Philadelphia Eagles at Lincoln Financial Field. The team...
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