The San Francisco 49ers have released the list of inactive players for their Week 10 matchup against the Los Angeles Rams. These seven players will not suit up for the game.
Inactives:- OL Connor Colby
- DT Alfred Collins (hip)
- RB Jordan James
- WR Ricky Pearsall (knee)
- QB Brock Purdy (toe)
- S Marques Sigle
- DL Sebastian Valdez
On Friday, the 49ers officially ruled out Pearsall for the matchup against the Los Angeles Rams. Several other players were listed as questionable, including quarterback Brock Purdy (toe), who was ultimately declared inactive for the game. The team reportedly hopes Purdy will be ready to return next weekend against the Arizona Cardinals.
The 49ers decided after last week to scrap the idea of Brock Purdy serving as the No. 2, source says. When he's ready to play, he'll be back in the starting lineup.
— Matt Maiocco (@MaioccoNBCS) November 9, 2025
Mac Jones will start at quarterback against the Rams, with Adrian Martinez once again serving as his backup.
The other players listed as questionable were defensive end Keion White (groin), defensive tackles Alfred Collins (hip) and Kalia Davis (ankle), and linebackers Tatum Bethune (thigh) and Dee Winters (both knees). Collins, is the only one from that group who is inactive.
A day later, the 49ers announced multiple roster moves ahead of the divisional showdown. Defensive lineman Mykel Williams was placed on injured reserve after suffering a torn ACL in last week's win over the New York Giants.
San Francisco also activated offensive lineman Ben Bartch from the injured reserve list and elevated defensive linemen Clelin Ferrell and Sebastian Valdez from the practice squad. However, Valdez was ultimately listed as inactive.