| 49ers Schedule |
| Day |
Date |
Opponent |
Time |
Result |
Score |
| Preseason |
| Fri | 8/14 | Broncos | 7:00p | W | 17-16 |
| Sat | 8/22 | Raiders | 5:15p | W | 21-20 |
| Sat | 8/29 | @ Cowboys | 5:00p | W | 20-13 |
| Fri | 9/4 | @ Chargers | 7:00p | L | 7-26 |
| Regular Season |
| Sun | 9/13 | @ Cardinals | 1:15p | W | 20-16 |
| Sun | 9/20 | Seahawks | 1:05p | W | 23-10 |
| Sun | 9/27 | @ Vikings | 10:00a | L | 24-27 |
| Sun | 10/4 | Rams | 1:15p | W | 35-0 |
| Sun | 10/11 | Falcons | 1:05p | L | 10-45 |
| BYE |
| Sun | 10/25 | @ Texans | 10:00a | L | 21-24 |
| Sun | 11/1 | @ Colts | 10:00a | L | 14-18 |
| Sun | 11/8 | Titans | 1:15p | L | 27-34 |
| Thur | 11/12 | Bears | 5:20p | W | 10-6 |
| Sun | 11/22 | @ Packers | 10:00a | L | 24-30 |
| Sun | 11/29 | Jaguars | 1:05p | W | 20-3 |
| Sun | 12/6 | @ Seahawks | 1:15p | L | 17-20 |
| Mon | 12/14 | Cardinals | 5:30p | W | 24-9 |
| Sun | 12/20 | @ Eagles | 10:00a | L | 13-27 |
| Sun | 12/27 | Lions | 1:05p | W | 20-6 |
| Sun | 1/3 | @ Rams | 10:00a | W | 28-6 |
| All Times Pacific |