Breakdown: There's no easing into the schedule for the 49ers, but that was the case to some degree last season as well. This time, the 49ers open at home against Green Bay before visiting Seattle in a Sunday night game. A home game against Indianapolis follows, meaning the 49ers' first three games are against opponents that were playoff teams last season. A Thursday night game at St. Louis follows, a big challenge after the 49ers failed to defeat the Rams last season.