The following is the announced San Francisco 49ers 2010 schedule. The dates and times were announced on Tuesday, April 20. All listed times are Pacific.
Preseason
Date TBA - @Colts - Time TBA
Sun 8/22 - Vikings - 5:00pm
Date TBA - @Raiders - Time TBA
Date TBA - Chargers - Time TBA
Regular Season
Sun 9/12 - @Seahawks - 1:15pm
Mon 9/20 - Saints - 5:30pm
Sun 9/26 - @Chiefs - 10:00am
Sun 10/03 - @Falcons - 10:00am
Sun 10/10 - Eagles - 5:20pm
Sun 10/17 - Raiders - 1:15pm
Sun 10/24 - @Panthers - 10:00am
Sun 10/31 - Broncos - 10:00am (London)
BYE
Sun 11/14 - Rams - 1:15pm
Sun 11/21 - Buccaneers - 1:05pm
Mon 11/29 - @Cardinals - 5:30pm
Sun 12/5 - @Packers - 10:00am
Sun 12/12 - Seahawks - 1:05pm
Thur 12/16 - @Chargers - 5:20pm
Sun 12/26 - @Rams - 10:00am
Ex-49ers LB highlights practice intensity shift after leaving San Francisco
By David Bonilla
Jan 26
The San Francisco 49ers endured another injury-plagued campaign in 2025. Despite the setbacks, the team still won 12 games and reached the postseason, leaving many to wonder how much further it could have advanced had several key contributors remained healthy.
As injuries have...
49ers mailbag: Will SF trade Mac Jones? Is there anything to electrical substation talk? Will 49ers be spenders in free agency?
By Marc Adams
Jan 31
Can't get enough of the San Francisco 49ers? We can help with that. We're back with a brand-new 49ers Webzone Mailbag. We asked for your best 49ers questions, and you came through with several good ones. Thank you for submitting those.
Before we jump into the mailbag, be sure...
Why the 49ers lost the numbers game up front—and what must change in 2026
By Jack Stewart
Jan 24
Four or five. Or maybe six.
Another out in the route or held in.
There are three things every quarterback needs: time, good pass catchers, and a good running game.
That first set of numbers above refers to how many players a team must use to get pressure on the quarterback....
49ers were prepared to lose assistant to Robert Saleh, Titans—but move now unlikely
By David Bonilla
Jan 25
The San Francisco 49ers appeared poised to lose assistant defensive line coach Greg Scruggs to newly hired Tennessee Titans head coach Robert Saleh, the team's former defensive coordinator. However, that move now appears unlikely following a correction from NBC Sports Bay...