The latest injury is to pass rusher Dee Ford, who Lynch said came in with some neck stiffness this week.
"We sent him for some imaging, and we're waiting to kind of hear those results here this morning," Lynch added. "We'll let you know as we know."
Tight end George Kittle suffered a knee sprain right before halftime during the 49ers' loss to the Arizona Cardinals this past weekend. He has not practiced yet this week but could still play on Sunday.
"He did sprain his knee," Lynch said. "Is it out of the question that he plays? No. George is obviously very important, and George is one of those guys who's going to want to play every time, so we have to be very judicious. But that's not to say we're ruling it out."
Lynch notes that there is the added element of getting on a plane to travel to the East Coast and how Kittle's knee could respond to the journey.
"We'll see what he's going to do today," Lynch continued. "I don't know how much he's going to try to do. I think it truly will be a game-time decision for George. He's so important to us. We've really got to be smart. That could be being smart, and he finds a way to play. It could be we decide to wait another week."
Lynch feels optimistic that Brandon Aiyuk (hamstring) will make his NFL debut this weekend, saying the rookie wide receiver is "trending in the right direction."
Like Aiyuk, center Ben Garland (ankle) has practiced this week and done an excellent job.
"I think we're going to kind of let that one play out," Lynch added. "That's another one that on these plane rides, sometimes, you get there and it doesn't feel so good. He'll be probably moving towards (a) game-time (decision)."
You can listen to the entire conversation with Lynch below.
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