The San Francisco 49ers are preparing for their Week 5 contest against the Seattle Seahawks on Sunday at Lumen Field in Seattle, Washington.
Ahead of practice, the 49ers announced that recently signed practice squad wide receiver Dante Pettis had been placed on injured reserve after suffering a calf injury during his second practice with the team.
The 49ers filled Pettis' spot by signing wide receiver Xavier Smith to the practice squad.
As expected, wide receiver Mike Evans was among the players limited in practice as he continues to deal with the rib injury he suffered in Week 3.
Mike Evans limited in practice on Wednesday pic.twitter.com/wX4IS8MW3k
— Matt Lively (@mattblively) October 7, 2026
Running back Kaelon Black was also limited while dealing with an illness.
Fullback Kyle Juszczyk suffered a hyperextended knee and bone bruise against the Denver Broncos and is expected to miss time. His name was among those listed as non-participants in Wednesday's practice.
Defensive lineman Mykel Williams continues to work his way back from an ACL injury. He was limited on Wednesday but expects to be activated from the physically unable to perform (PUP) list ahead of Sunday's game against the Seahawks.
Mykel Williams is hoping to be activated for Sunday. Would add a much needed body on that #49ers defensive line pic.twitter.com/60nMUelc8r
— Matt Lively (@mattblively) October 7, 2026
Below are Wednesday's practice participation reports for both the 49ers and Seahawks, which were provided by the 49ers Communications staff.
San Francisco 49ers Wednesday Practice
Did Not Participate In Practice- DE Nick Bosa (knee, calf)
- LB Dre Greenlaw (resting player)
- FB Kyle Juszczyk (knee)
- RB Christian McCaffrey (resting player)
- S Marques Sigle (ankle)
- CB Upton Stout (shoulder)
- DT James Thompson (ankle)
- T Trent Williams (resting player)
Limited Participation in Practice
- RB Kaelon Black (illness)
- WR Mike Evans (ribs)
- DE Mykel Williams (knee)
Full Participation in Practice
- LB Jaden Dugger (shoulder)
- DE Romello Height (hand)
Seattle Seahawks Wednesday Practice
Did Not Participate In Practice- WR Jaxon Smith-Njigba (resting player)
- LB Chazz Surratt (calf)
- RB Zach Charbonnet (knee)
- WR Irvin Charles (knee)
- RB George Holani (ribs)
- LB Tyrice Knight (ankle)
- CB Nehemiah Pritchett (ankle)
- G Beau Stephens (knee)
- DT Leonard Williams (ankle)
Full Participation in Practice
- LB Patrick O'Connell (thumb)
- S Ty Okada (hamstring)
More info on: Kaelon Black, Nick Bosa, Jaden Dugger, Mike Evans, Dre Greenlaw, Romello Height, Kyle Juszczyk, Christian McCaffrey, Marques Sigle, Xavier Smith, Upton Stout, James Thompson, Mykel Williams, Trent Williams
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