The San Francisco 49ers will be underdogs for the second time in 2026 when they hit the road vs. the Seattle Seahawks.
49ers open as underdogs for 2nd time vs. division opponent in Week 5
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49ers open as 3-point underdogs in Week 5 clash against Seahawks
By David Bonilla
Oct 5
For only the second time this season, and the first time since Week 1, the San Francisco 49ers are entering a game as underdogs. Oddsmakers currently have the 49ers as three-point underdogs for their Week 5 matchup against the Seattle Seahawks at Lumen Field.
The 49ers are one...
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