The San Francisco 49ers are facing the Denver Broncos in a Week 4 matchup at Levi's Stadium in Santa Clara, California.
Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available.
Players are listed in order of most recent report.
S Marques Sigle
After exiting earlier in the game and returning, Marques Sigle went down during a fourth-quarter kick return and was slow to get up. He eventually headed to the locker room with assistance.
CB Upton Stout (shoulder, questionable)
Upton Stout headed to the locker room in the fourth quarter. The CBS broadcast announced that he is questionable to return due to a shoulder injury.
Update: Stout returned to the game.
FB Kyle Juszczyk (knee, out)
Kyle Juszczyk took a hit to his knee after a fourth-quarter catch and was slow to get up. He walked slowly to the sideline with assistance from medical staff. Juszczyk eventually headed to the locker room.
The 49ers ruled Juszczyk out for the rest of the game with a knee injury.
#49ers @SutterHealth Injury Update: Kyle Juszczyk is out for the remainder of the game (knee).
— San Francisco 49ers (@49ers) October 4, 2026
More info on: Kyle Juszczyk, Marques Sigle, Upton Stout
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