The San Francisco 49ers will go into a vital Monday Night Football matchup vs. the Indianapolis Colts without two starters.
Kyle Shanahan delivers rough 49ers injury update ahead of Week 16 game
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49ers vs. Colts final injury report: Ricky Pearsall, Renardo Green ruled out for MNF
By David Bonilla
Dec 20, 2025
The San Francisco 49ers are preparing for their Week 16 contest against the Indianapolis Colts on Monday at Lucas Oil Stadium in Indianapolis, Indiana. Both teams have released their official injury reports, which are provided below.
San Francisco 49ers
Out
CB Renardo Green...
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