The 49ers welcome the Panthers for a Week 12 prime-time clash between two teams working to secure a playoff spot.
Panthers vs 49ers: How to watch ‘Monday Night Football’ on ESPN
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49ers vs. Panthers in Week 12: How to watch, stream, and listen, plus odds
By Site Staff
Nov 19, 2025
The San Francisco 49ers head back home to Levi's Stadium to take on the Carolina Panthers on ESPN's Monday Night Football. This matchup marks the 24th all-time meeting between the two teams, with the Panthers leading the series 13–10. The 49ers host the Panthers for the...
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