The San Francisco 49ers lost Nick Bosa to a knee injury in the first quarter, and in the second quarter, they may have lost Mykel Williams.
49ers lose another key pass rusher to injury early vs. Cardinals
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49ers vs. Cardinals injury updates: Bosa ruled out with knee injury
By David Bonilla
Sep 21, 2025
The San Francisco 49ers are facing the Arizona Cardinals at Levi's Stadium in Week 3. Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available.
Players are listed in order of most recent...
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