After winning their first two games of the season, the San Francisco 49ers return home in Week 3 to host the Arizona Cardinals at Levi's Stadium.
49ers opened as underdogs in home opener vs. Cardinals
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49ers favored against Cardinals despite injuries, Brock Purdy uncertainty
By David Bonilla
Sep 16, 2025
This Sunday, the San Francisco 49ers will host the Arizona Cardinals at Levi's Stadium in a pivotal NFC West matchup between two of the division's three undefeated teams. The 49ers, favored in their first two road games against Seattle and New Orleans, enter Week 3 as favorites...
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