2025 NFL Draft as it happened: 49ers’ Day 2 picks, highlights, news, analysis

What to Know The San Francisco 49ers used their first pick in the 2025 NFL Draft on Georgia EDGE Mykel Williams at No. 11 overall on Thursday. Day 2 of the 2025 draft begins at 4 p.m. PT on Friday, April 25, outside historic Lambeau Field in Green Bay, Wis. The 49ers have 10 draft selections remaining, including one second-round pick at No. 43. After a 6-11 record to end the 2024 NFL season, the 49ers are looking to strike gold in the draft with a youth infusion that can help them return to the Super Bowl. NBC Sports Bay Area's 49ers insider Matt Maiocco predicted who San Francisco will select with its second-round pick in his latest NFL mock draft. Follow live updates on the latest draft selections, highlights, news and analysis from the draft in Green Bay: