The 2022 NFL schedule is here, and sportsbooks have already released moneylines and totals for Week 1 contests.
2022 NFL Schedule Release: Week 1 lines and favorite bets
Published May 12, 2022 at 5:40 PM
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Complete 2022 San Francisco 49ers Schedule Revealed
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The NFL revealed its complete 272-game 2022 regular-season schedule on Thursday at 5:00 p.m. PT. NFL Kickoff Weekend will begin on Thursday, September 8, culminating with Super Bowl LVII on February 12, 2023, at State Farm Stadium in Glendale, Arizona.
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