The 2022 NFL regular season will kick off with a marquee showdown in Los Angeles as the Rams will host the Buffalo Bills on Sept. 8. Check the complete Week 1 schedule in addition to every team's home opener.
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- 2022 NFL schedule release: Bills-Rams kicks off regular season; complete Week 1 schedule; all 32 home openers
2022 NFL schedule release: Bills-Rams kicks off regular season; complete Week 1 schedule; all 32 home openers
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