Jim Harbaugh, Alex Smith, Frank Gore, Patrick Willis and the rest of the San Francisco 49ers kick off the 2012 season with a trip to Lambeau Field to face Aaron Rodgers and the Green Bay Packers.
The 49ers (0-0) finished the preseason 3-1 while the Packers (0-0) finished the preseason 2-2.
The game kicks off at 1:25 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
Within our 2012 NFL Pick 'Em Contest, 76% of fans fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 67% of fans believe that the Packers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.