Curtis Holcomb likely out for season

The San Francisco 49ers are playing the Denver Broncos at Empower Field at Mile High. The Niners entered the matchup without defensive lineman Arik Armstead (foot), offensive lineman Daniel Brunskill (hamstring), running back Tyrion Davis-Price (ankle), and tight end Tyler Kroft (knee). All four were among the six inactive players for the 49ers. Below are the 49ers-Broncos in-game injury updates. LB Azeez Al-Shaair (knee, out) Azeez Al-Shaair left the game with just over four minutes left in the first half. The 49ers announced that he suffered a knee injury and is questionable to return. Update: Al-Shaair

Brock Purdy is now one injury away from starting. While the San Francisco 49ers have expressed a lot of confidence in the last overall pick in this year's draft, having the rookie lead a championship-caliber roster probably isn't ideal. Veteran Jimmy Garoppolo is the starter moving forward following the season-ending injury to Trey Lance, last year's No. 3 overall pick. Lance will undergo surgery today on the broken ankle suffered in the first quarter of Sunday's 27-7 win over the Seattle Seahawks. Purdy hasn't even been active in San Francisco's two games this season. However, he may suit up for Sunday's matchup against the Denver Broncos. Fullback Kyle Juszczyk

NFL Network's Tom Pelissero reported on Monday morning that San Francisco 49ers quarterback Trey Lance is undergoing surgery this morning for his fractured and dislocated ankle. #49ers QB Trey Lance is undergoing surgery this morning for his fractured and dislocated ankle, per source. One small bit of good news: My understanding is not a compound fracture like Dak Prescott's. But still a season-ending injury.— Tom Pelissero (@TomPelissero)

The San Francisco 49ers announced that quarterback Trey Lance underwent successful surgery on Monday. The second-year player suffered what was reported as a broken ankle during the first quarter of Sunday's 27-7 win over the Seattle Seahawks, ending his 2022 season. "San Francisco 49ers quarterback Trey Lance underwent successful surgery on his injured right ankle this morning, an injury that occurred in yesterday's game versus the Seattle Seahawks," the 49ers said in a statement. The team also provided more details on the injury itself. "Surgery was performed at Stanford Hospital and repaired two injuries to Lance's ankle, a fibula fracture, and ligament disruption," the 49ers announced. "Lance will start the rehab process, and head team physician