Curtis Holcomb likely out for season

The San Francisco 49ers will be without several playmakers on Sunday when they face the New York Jets at MetLife Stadium. That includes tight end George Kittle on offense and cornerback Richard Sherman and pass rusher Dee Ford on defense. The good news is that some reinforcements — at least on offense — appear to be on their way. Adam Schefter of ESPN is reporting that wide receivers Brandon Aiyuk and Mohamed Sanu are expected to make their 49ers debuts. Aiyuk, a rookie, will be making his NFL debut. Help for 49ers: WR Mohamed Sanu, who played under Kyle Shanahan in Atlanta, is expected to

The San Francisco 49ers are preparing for their Week 2 contest against the New York Jets on Sunday at MetLife Stadium in East Rutherford, New Jersey. Tight end George Kittle missed his third practice of the week and has been ruled "out" of Sunday's game due to a knee injury. Kittle suffered the injury just before halftime during Week 1's loss to the Arizona Cardinals. Cornerback Jason Verrett is the only other 49ers player who has officially been ruled "out" — other than those on injury lists. Defensive end Dee Ford experienced some neck stiffness this week and underwent further tests. He has been listed as "questionable" to play against the Jets. On the Jets' side, wide receiver Jamison Crowder has been ruled out due to a hamstring injury.

The San Francisco 49ers were the lone NFC West squad that failed to win its 2020 opener. Kyle Shanahan's team lost 24-20 to the Arizona Cardinals at Levi's Stadium. Earlier on Sunday, the Seattle Seahawks beat the Atlanta Falcons 38-25. Later, the Los Angeles Rams beat the Dallas Cowboys 20-17 in the first game at SoFi Stadium — albeit without fans to watch. That means the 49ers start their 2020 season, which the team was so eager to begin as it attempts to make amends from February's Super Bowl loss, in last place within the NFC West.