Curtis Holcomb likely out for season

It looks like Deommodore Lenoir will be counted on by the San Francisco 49ers right out of the gate. The rookie cornerback is warming up with the first-team defense ahead of this morning's regular-season opener against the Detroit Lions. That is a good indication that Lenoir will be the starter opposite Jason Verrett when the defense takes the field. Rookie fifth-round pick CB Deommodore Lenoir is lining up with first-team defense during warmups. #49ers— Eric Branch (@Eric_Branch)

As Joe Staley embarks on his first season as a member of the media, his former team embarks on a potential bounceback campaign to prove that 2020's six-win effort was a fluke. Staley believes the San Francisco 49ers will do just that. Staley, a rookie again, this time with NBC Sports Bay Area, likes what he sees from the stacked Niners roster. The team isn't far removed from the 2019 team that included Staley and reached the Super Bowl, falling just short of a championship. Injuries played a big part in last season's lack of success. However, a healthier 2021 should result in a more desirable outcome. "I think, definitely, there is something to be said about staying healthy because I do believe this is a really loaded roster," Staley said on KNBR's Papa &

As the excitement builds for the kickoff of the NFL regular season, we gain insight into media expectations via the final 2021 preseason power rankings for the San Francisco 49ers. For the avid NFL football fan, there is perhaps no act so trivial, yet so enjoyable, than participating in an NFL mock draft. I challenge you to identify an activity countless fans engage in for fun despite their realistic expectations of complete and utter failure. Similar is the process of preseason power rankings, which can be quite entertaining to review at the conclusion of the season -- provided you weren't the one doing the ranking. The glaring difference between the two is power rankings are written with the intention of being correct; but like mock drafts or final roster

After a long offseason, training camp and preseason to follow up everything that they went through in 2020, it's safe to say the San Francisco 49ers are itching to get their 2021 regular season underway this Sunday against the Detroit Lions (1 p.m. ET/10 a.m. PT). And based on what tight end George Kittle and defensive end Nick Bosa said after practice on Thursday, it sounds like the 49ers will be heading into this weekend's opener at Ford Field in Detroit with momentum at their backs after six successful weeks of preparation. Last season saw the 49ers' hopes of defending their 2019 NFC Championship go up in smoke after being decimated by a seemingly never-ending string of significant injuries. Then, to add insult to injury, the 49ers were forced to spend the