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Interim head coach Jim Tomsula led the San Francisco 49ers to a 38-7 rout over the visiting Arizona Cardinals in their final game of the 2010 season.
In what could be his last game in San Francisco, Alex Smith was 15 of 29 for 276 yards and two touchdowns.
Brian Westbrook carried the ball for 79 yards and two more touchdowns.
Next, the 49ers look to the offseason to hire a new G.M. and head coach. Stay here during the entire offseason as 49erswebzone.com covers the G.M. hiring, head coach search, free agency, the NFL Draft, and much more.
Brandon Aiyuk's best game of the season ends in frustration as 49ers collapse against Cardinals
By David Bonilla
Oct 6
After a series of sluggish performances since becoming one of the NFL's highest-paid wide receivers, Brandon Aiyuk played like a man intent on silencing his critics. The star wideout finished Sunday's game against the Arizona Cardinals with eight catches for 147 yards on 12...
49ers vs. Cardinals: How to watch, stream, and listen to the Week 5 matchup, plus odds
By Site Staff
Oct 2
The San Francisco 49ers face the Arizona Cardinals in a divisional matchup at Levi's Stadium, marking the 66th meeting in a series that San Francisco leads 36-29 all-time. The 49ers aim for their fifth consecutive win in the series and hope to improve their home record to 21-14...
San Francisco 49ers head coach Kyle Shanahan spoke to reporters ahead of Wednesday's practice as the team prepares for its Week 5 matchup against the Arizona Cardinals. Here's everything he shared.
Transcript provided by the San Francisco 49ers Communications staff.
Opening...
San Francisco 49ers linebacker Fred Warner left Sunday's game against the New England Patriots with an ankle injury. Fortunately, tests revealed it's not a long-term issue, and Warner is considered day-to-day.
While Warner did not practice on Wednesday, he made it clear that...
