The game kicks off at 5:20 pm and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be aired on NFL Network.
Within our NFL Pick 'em Contest, 39% of fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores app, 28% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.