Gameday: San Francisco 49ers at San Diego Chargers

The San Francisco 49ers' stock went from potential contenders to hoping for a playoff spot during their two-game, home losing streak and will now go on the road to challenge the lone undefeated team in the NFL, the Arizona Cardinals, whose stock could not be higher. Here we discuss the odds and analysis from a betting perspective. When: Sunday October 10th, 2021 1:25pm PT (FOX) Where: State Farm Stadium, Glendale, Arizona Line: 49ers +5.5, over/under 50.5 Arizona Cardinals The Arizona Cardinals are coming off of their biggest win of the season after going into the Los Angeles Rams' home as 4-point underdogs and completely smashing LA by the score of 37-20 to emerge on top of the NFC West and the only undefeated team

The San Francisco 49ers announced that they have activated defensive tackle Maurice Hurst from injured reserve. This past week, the team had opened his practice window and needed to decide on his roster status within 21 days. Hurst suffered an ankle sprain on August 22 and was placed on injured reserve on September 1. San Francisco signed him to a one-year deal on April 23. The 49ers also opened the practice window of cornerback Davontae Harris this past week but opted not to activate the defensive back just yet. The Raiders made Hurst a fifth-round selection out of Michigan in 2018. He registered 27 tackles, a tackle for a loss, 0.5 sacks, six quarterback hits, and a pass defensed through 11 games with Las Vegas last season, per Pro Football

After a difficult loss to the Green Bay Packers on Sunday Night Football, the San Francisco 49ers are back for their second straight home game at Levi's Stadium versus another potential NFC contender in the Seattle Seahawks. The Niners lost the bout with the Packers in a heartbreaking fashion in a game that was decided in the final minute of play. The beginning of the game seemed like it was going to be a dominant, statement victory for Green Bay as they got off to a 17-0 lead by the time one minute was remaining in the first half. However, from there, the 49ers' offense led a comeback all the way to the end of the game when quarterback Jimmy Garapolo threw a touchdown pass to fullback Kyle Juscyk to make the score 28-27 with 37 seconds left. Unfortunately for San Fransisco,

"I mean, I'm going to do everything I can to be on the field on Sunday," George Kittle told reporters on Friday. "And then, if my body says I can go, I'll be out there." It sounds like we can expect the San Francisco 49ers star tight end to be out there for the team's first divisional matchup of the season. Despite being listed as "questionable" for the game, per multiple reports, Kittle is expected to be on the field at Levi's Stadium this afternoon when the Niners host the Seattle Seahawks. "While officially a game-time decision, SF has optimism that Kittle will be correct," notes Ian Rapoport of NFL