The San Francisco 49ers are facing the Washington Commanders in a Week 6 matchup at Levi's Stadium in Santa Clara, California.
Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available, so check back throughout the game for the latest developments.
Players are listed in order of the most recent injury updates.
LB Luke Gifford (groin, questionable)
In the third quarter, the 49ers announced that Luke Gifford is questionable to return due to a groin injury.
WR Mike Evans (Achilles, out)
Mike Evans was slow to get up after a second-quarter catch and headed to the locker room before halftime, clearly uncomfortable. He has been playing through a rib injury and has experienced Achilles soreness over the past week.
The 49ers initially announced that Evans is questionable to return due to an Achilles injury. He was later ruled out.
#49ers @SutterHealth Injury Update: Mike Evans (achilles) is out for the remainder of the game and Luke Gifford (groin) is questionable to return.
— San Francisco 49ers (@49ers) October 20, 2026
More info on: Mike Evans, Luke Gifford
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