The San Francisco 49ers open the 2026 regular season on the road as they take on the Los Angeles Rams at the Melbourne Cricket Ground in Melbourne, Australia, marking the NFL's first-ever regular-season game in Australia. This matchup marks the 155th overall meeting between the two teams and the third time in series history that they have faced off in Week 1. San Francisco is 3-1 in international play and aims to win its fourth consecutive game outside of the United States.
The 49ers lead the all-time series against the Rams, 79-72-3, and look to improve to 42-35-1 as the road team. San Francisco has won six of its previous seven road matchups against Los Angeles and looks to open the regular season with a win for the fourth consecutive season.
49ers in the preseason
San Francisco finished the preseason with a 2-1 record. Offensively, the team registered 308.0 yards and 24.0 points per game while averaging 4.5 yards per play. The 49ers' defense held opponents to 253.0 yards per game and 16.0 points per game.
The 49ers Communications staff provided the above breakdown.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Thursday, September 10 at 5:35 p.m. PT
Where is the game being played?
Melbourne Cricket Ground in Melbourne, Australia
Who are the head coaches?
49ers: Kyle Shanahan
Rams: Sean McVay
Betting Odds
As of September 4, the Rams are favored by 3.5 points in this game, with an over/under set at 48.5 points, per BetMGM.
What channel is the game on?
Network: Netflix
Play-By-Play: Noah Eagle
Color Analyst: Luke Kuechly
Sideline Reporter: MJ Acosta-Ruiz
What areas will receive the broadcast?
Anyone with a Netflix subscription will be able to watch the game. Thanks to the NFL's simulcast rules, Bay Area fans will also be able to watch the Netflix broadcast on NBC Bay Area.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Rams Radio
Los Angeles-area fans can listen on ESPN 710 AM, where J.B. Long and Maurice Jones-Drew will call the game.
National Radio
Fans can listen to the game on Westwood One, where Ryan Radtke and Isaac Bruce will call the game.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 154
Series Record: 49ers lead series 79-72-3
49ers Home Record vs. Rams: 49ers lead series 38-37-2
49ers Away Record vs. Rams: 49ers lead series 41-35-1
First Meeting: 10/1/50, Rams win 35-14, at SF
Last Meeting: 11/9/25, Rams win 42-26, at SF
Current Streak: Lost 1
Longest 49ers Win Streak: 17 (12/17/90 – 12/27/98)
Longest Rams Win Streak: 10 (11/29/70 – 9/28/75)
Most 49ers Points: 48 (12/27/87): 49ers win 48-0, at SF
Most Rams Points: 56 (11/9/58): Rams win 56-7, at LA
49ers Shutouts: 9 (Last 9/12/16), 49ers win 28-0, at SF
Rams Shutouts: None
49ers Notes
- The 49ers made their fourth playoff appearance in the past five seasons last year.
- QB Brock Purdy passed for 2,167 yards and 20 TDs in nine games last year and totaled 147 rushing yards and three TDs. Had a TD pass in eight of his nine games in 2025 and threw for 295+ passing yards in three of his last four games last season.
- RB Christian McCaffrey finished second with 2,126 scrimmage yards (1,202 rushing, 924 receiving) and third with 17 TDs (10 rushing, seven receiving) in 2025. Became the sixth player since 1990 with 2,000+ scrimmage yards in three career seasons. Is one of two players (HOFer LaDainian Tomlinson) with three seasons of 2,000+ scrimmage yards and 15+ TDs. Has 95+ scrimmage yards in all six career games vs. LAR and has a TD in three of his last four vs. LAR.
- WR Mike Evans ranks first with 13,052 receiving yards and second with 108 TD catches since 2014. Has 81 games with a TD catch, the 10th-most all time. Can make his 49ers debut after spending the last 12 seasons with TB. Can become the sixth player all time with 10+ TD receptions in seven career seasons.
- WR Deebo Samuel recorded 72 catches for 727 yards and five TD receptions with WAS in 2025. Had 334 receptions for 4,792 receiving yards and 22 TD catches with SF from 2019-24.
- TE George Kittle ranked tied for fifth among TEs with seven TD catches in 2025. Is one of five TEs all time with 1,000+ receiving yards in four career seasons. Had nine receptions for 84 yards and a TD in the last meeting.
- DL Nick Bosa ranks eighth with 64.5 sacks since 2019.
- LB Fred Warner has 115+ tackles in seven of his eight career seasons. Aims for his third consecutive game vs. LAR with 12+ tackles and has a PD in two of his last three vs. LAR.
- CB Upton Stout was one of two rookies to record 80+ tackles (82) and 5+ PD (five), and a FF last season.
- DB Deommodore Lenoir recorded 61 tackles, four TFL, five PD, and two INTs in 2025. He had a PD in two of his last three vs. LAR.
Rams Notes
- QB Matthew Stafford was named the 2025 AP NFL MVP. Led the NFL with 4,707 passing yards and a career-high 46 TD passes in 2025, joining Tom Brady as the only QBs ever with 4,500+ passing yards and 40+ TD passes in three career seasons. Aims for his third consecutive game vs. SF with 280+ passing yards and 3+ TD passes.
- RB Kyren Williams ranks sixth among RBs with 3,695 rushing yards since 2023. Had 13 TDs (10 rushing, three receiving) and a career-high 1,533 scrimmage yards (1,252 rushing, 281 receiving) in 2025. Has two TDs in four of his five career games vs. SF.
- WR Puka Nacua led the NFL with 129 receptions, ranked second with a career-high 1,715 receiving yards, and tied for sixth with 10 TD catches last season. Aims for his third consecutive game vs. SF with a TD reception. Has 115+ receiving yards in two of his last three Week 1 games.
- WR Davante Adams ranks seventh all time with 117 TD receptions. Led the NFL with 14 TD catches in 2025 and became the fifth player in NFL history with 10+ TD receptions in seven career seasons. Had six catches for 77 yards and a TD in the last meeting.
- DE Myles Garrett had 23 sacks in 2025 with CLE, the most in a single season since 1982. Has recorded a sack in 79 career games, tied with HOFers DeMarcus Ware and Reggie White for the most games with a sack in a player's first nine seasons since 1982. Was named the 2025 Defensive Player of the Year, earning his second career DPOY award (2023).
- DT Aaron Donald returns to the Rams after retiring in 2024. Is the franchise leader in sacks (111) and TFL (176). Is one of three players to earn DPOY honors three times (2017-18, 2020).
- LB Nate Landman recorded a career-high 132 tackles in 2025 and ranked tied for second with four FFs. Aims for his third consecutive game vs. SF with 10+ tackles.
- LB Byron Young had career highs in tackles (82) and sacks (12) in 2025.
- DE Kobie Turner recorded seven sacks and nine TFL in 2025.
- CB Emmanuel Forbes ranked tied for third with 18 PD last season. Had a PD in 11 games in 2025.
- CB Trent McDuffie recorded a FF, seven PD, and an INT in 2025 with KC.
- S Kam Curl recorded a career-high 122 tackles in 2025 and added five PD and two INTs.
More info on: Nick Bosa, Mike Evans, George Kittle, Deommodore Lenoir, Christian McCaffrey, Brock Purdy, Deebo Samuel, Upton Stout, Fred Warner
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