The San Francisco 49ers are preparing for their Week 4 contest against the Jacksonville Jaguars on Sunday at Levi's Stadium in Santa Clara, California. Both teams have released their official injury reports, which are provided below.
San Francisco 49ers
Out
WR Jordan Watkins (calf), DT C.J. West (thumb)
Questionable
G Connor Colby (groin), CB Renardo Green (neck), WR Jauan Jennings (ankle, shoulder), QB Mac Jones (knee), WR Ricky Pearsall (knee)
Jacksonville Jaguars
Out
G Wyatt Milum (knee)
Questionable
LB Yasir Abdullah (hamstring), WR Dyami Brown (shoulder)
Injury Notes
Wide receiver Jauan Jennings returned to practice for the first time in two weeks after missing Sunday's game against the Arizona Cardinals due to shoulder and ankle injuries. Reports indicated Jennings still appeared limited by the ankle issue, but his presence on the field is a positive sign ahead of this weekend's game.
Jennings *did* appear to be affected by his ankle injury while running routes. We'll see what Kyle Shanahan says about his game-day designation in roughly an hour. https://t.co/AzCE7WdifB
— Matt Barrows (@mattbarrows) September 26, 2025
Jennings and second-year wideout Ricky Pearsall are questionable to play on Sunday.
Cornerback Renardo Green (neck) did not participate in practice but was seen working on the side. Defensive tackle C.J. West remains sidelined after undergoing surgery on a broken thumb on Tuesday, while defensive end Yetur Gross-Matos continues to recover from a knee injury.
As expected, quarterback Brock Purdy practiced for the third straight day after missing his second consecutive game due to a toe injury. He has been cleared to start against the Jaguars.
Below are Friday's practice participation reports for both the 49ers and Jaguars, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice
CB Renardo Green (neck), DE Yetur Gross-Matos (knee), WR Jordan Watkins (calf), DT C.J. West (thumb)
Limited Participation in Practice
G Connor Colby (groin), WR Jauan Jennings (ankle, shoulder), QB Mac Jones (knee), WR Ricky Pearsall (knee)
Full Participation in Practice
DT Kalia Davis (ankle), CB Deommodore Lenoir (illness), RB Christian McCaffrey (not injury related - resting player), QB Brock Purdy (left shoulder, toe), DE Mykel Williams (wrist), T Trent Williams (not injury related - resting player)
Jacksonville Jaguars Friday Practice
Limited Participation in Practice
LB Yasir Abdullah (hamstring), WR Dyami Brown (shoulder), G Ezra Cleveland (ankle), G Patrick Mekari (elbow), G Wyatt Milum (knee)
Full Participation in Practice
WR Brian Thomas (wrist), RB Bhayshul Tuten (shoulder)