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Defensive tackle Arik Armstead is dealing with a foot injury and did not practice. When asked if it was a similar issue to what he dealt with last season (plantar fasciitis), head coach Kyle Shanahan responded, "Not sure exactly. I know it's his foot, but not sure how similar it is."
Also missing from practice were running back Jordan Mason, who is dealing with a hamstring issue, and wide receiver Ray-Ray McCloud, who is recovering from a rib injury.
Guard Spencer Burford returned to practice on Monday after being among the 49ers' inactive players against the Seattle Seahawks last week. He is working through a knee injury. Burford was a limited participant during Wednesday's practice.
For the Eagles, defensive tackle Fletcher Cox didn't practice due to a groin injury. Right tackle Lane Johnson said he expects to play against the 49ers after missing Sunday's game with a groin injury. He was among the offensive players who were limited practice participants.
San Francisco 49ers Wednesday Practice
Did Not Participate In Practice
DT Arik Armstead (foot), RB Jordan Mason (hamstring), WR Ray-Ray McCloud (rib), T Trent Williams (not injury related - resting player)
Limited Participation in Practice
G Spencer Burford (knee)
Philadelphia Eagles Wednesday Practice
Did Not Participate In Practice
TE Grant Calcaterra (ankle), DT Fletcher Cox (groin), LB Zach Cunningham (hamstring), S Justin Evans (knee), TE Dallas Goedert (forearm)
Limited Participation in Practice
WR A.J. Brown (thigh), DT Jordan Davis (hamstring), T Lane Johnson (groin), WR Julio Jones (knee), WR DeVonta Smith (knee), RB D'Andre Swift (ankle), DT Milton Williams (concussion)