Quarterback Jimmy Garoppolo will miss his second consecutive game after suffering an ankle injury during Week 2. That means another start for Nick Mullens, who filled in well for the injured starter this past weekend against the New York Giants.
"If Jimmy could have played this week, he'd be out there," head coach Kyle Shanahan told reporters on Friday.
Running back Raheem Mostert (knee) and linebacker Dre Greenlaw (quadricep), like Garoppolo, did not practice this week and will each miss his second consecutive game. Also ruled out are cornerbacks Emmanuel Moseley (concussion) and Ahkello Witherspoon (hamstring).
The good news is that the 49ers offense will have tight end George Kittle (knee) and wide receiver Deebo Samuel on the football field against the Eagles. Both made it through a full week's worth of practices and Shanahan said on Friday that both will play.
Samuel is returning from a Jones fracture suffered in June and still needs to be activated to the 53-man roster. Expect that to happen on Saturday.
Below are the official injury reports for the 49ers and Eagles, which were provided by the 49ers Communications staff. Also included are Friday's practice participation reports.
San Francisco 49ers
Out
DE Dee Ford (back), QB Jimmy Garoppolo (ankle), LB Dre Greenlaw (quadricep), CB Emmanuel Moseley (concussion), RB Raheem Mostert (knee), TE Jordan Reed (knee), CB Ahkello Witherspoon (hamstring)
Questionable
CB K'Waun Williams (hip)
Philadelphia Eagles
Out
WR DeSean Jackson (hamstring), WR Alshon Jeffery (foot), CB Avonte Maddox (ankle), CB Trevor Williams (rib)
Doubtful
WR J.J. Arcega-Whiteside (calf)
Questionable
T Jason Peters (foot)
San Francisco 49ers Friday Practice
Did Not Participate In Practice
DE Dee Ford (back), QB Jimmy Garoppolo (ankle), LB Dre Greenlaw (quadricep), CB Emmanuel Moseley (concussion), RB Raheem Mostert (knee), TE Jordan Reed (knee), CB Ahkello Witherspoon (hamstring)
Limited Participation in Practice
CB K'Waun Williams (hip)
TE George Kittle (knee), RB Jerick McKinnon (ribs)
Philadelphia Eagles Friday Practice
Did Not Participate In Practice
DT Fletcher Cox (not injury related), WR DeSean Jackson (hamstring), CB Avonte Maddox (ankle), CB Trevor Williams (rib)
Limited Participation in Practice
WR J.J. Arcega-Whiteside (calf), WR Alshon Jeffery (foot), T Lane Johnson (ankle), T Jason Peters (foot)
Full Participation in Practice
G Jamon Brown (illness), T Jack Driscoll (illness), S Rudy Ford (groin), WR John Hightower (illness), C Jason Kelce (not injury related), RB Miles Sanders (glute)
