Los Angeles Rams running back Todd Gurley and cornerback Aqib Talib missed their third practice of the week leading to the team's matchup against the San Francisco 49ers on Sunday. Gurley has been listed with a quadricep issue while Talib has a rib injury.

The Rams released their injury report on Friday, and Gurley has been listed as doubtful for this weekend's game while Talib has been listed as out and will not play, according to head coach Sean McVay via the Los Angeles Times.

The 49ers offense is banged up itself and will be without both starting tackles, Joe Staley and Mike McGlinchey, as well as the team's only fullback, Kyle Juszczyk. Those are three key components on the league's No. 1 ranked rushing offense. Of course, Staley has been out since his injury during Week 2.

RELATED 49ers-Rams Injury Report: George Kittle questionable as division rivals hobble into NFC West showdown

Justin Skule has been playing in place of Staley while Daniel Brunskill will replace McGlinchey. The 49ers will try to get a little creative in replacing Juszczyk.