The San Francisco 49ers lost 43-16 to the Seattle Seahawks at CenturyLink Field on Sunday and dropped to 2-10 on the season.

Below is a mix of key player and team stats provided by the NFL, the 49ers, and Pro Football Focus.

Key Player Statistics

QB Nick Mullens completed 30-of-48 passes for a career-high 414 yards with two touchdowns and an interception. It marked the first time in his career he has thrown for 400-or-more yards.

Mullens' passer rating of 95.3 was the second-highest of his four starts and marks the first time the rating has risen from one week to the next.

Mullens' 414 passing yards on the day are the most by a 49ers QB since Tim Rattay registered 417 passing yards against Arizona on October 10, 2004.

Mullens is the first 49ers QB to throw for 400-or-more yards in a single game since Colin Kaepernick did so (412 yards) against the Green Bay Packers on September 8, 2013.

Mullens had a lot of success throwing downfield. He was 6-of-8 for 156 yards with a touchdown and a passer rating of 156.3 on throws of 10-or-more yards, according to Pro Football Focus.

WR Dante Pettis hauled in five receptions for 129 yards (25.8 average) and two touchdowns, all career highs. He hauled in touchdown passes of 17 and 75 yards from Mullens.

This marks the first time in his career that he has registered two-or-more touchdown receptions in a single-game. This marked the 11th time in franchise history, and first since WR J.J. Stokes vs. St. Louis (2 touchdown receptions) on November 26, 1995, that a 49ers rookie registered at least two touchdown receptions in a game.

Pettis now has four touchdown receptions on the season, including at least one in consecutive games. His four are the most by a member of the 49ers in his rookie season since WR Terrell Owens registered four touchdown receptions in 1996, and are tied for the fourth-most by a rookie in 49ers franchise history.

Pettis' 129 reception yards on the day are the fourth-most by a rookie in franchise history in a single game and are the most since WR Jerry Rice registered 241 receptions yards versus the Los Angeles Rams on December 9, 1985. His 129 receiving yards are the most by a member of the 49ers since WR Pierre Garçon registered 142 reception yards versus the Los Angeles Rams on September 21, 2017.

RB Jeff Wilson registered career highs with 15 carries for 61 yards on the ground along with eight receptions for 73 yards.

Wilson's eight receptions are the most by a 49ers RB since Carlos Hyde registered nine against Arizona on November 5, 2017.

RB Matt Breida hauled in three receptions for a career-high 51 receiving yards.

C Weston Richburg and G Mike Person had subpar games when it came to run blocking, according to Pro Football Focus. Richburg had a 35.4 run-block grade while Person had a 45.5 run-block grade.

DT DeForest Buckner registered two sacks on the day, bringing down Seahawks QB Russell Wilson for losses of one and five yards.

Buckner has now registered at least half a sack in four consecutive games, the longest streak of his career. He is the first member of the 49ers to register at least half a sack in four consecutive games since LB Aldon Smith accomplished the feat in Weeks 7-14 of the 2012 season.

Buckner's nine sacks are the most by a member of the 49ers in a single season since Aldon Smith registered 19.5 sacks in 2012.

Buckner has registered two-or-more sacks in a single game four times in his career and twice this season (2.5 sacks at Min. on 9/9/18).

DE Arik Armstead earned the top Pro Football Focus grade (73.1) on defense for the second time in three games. His 86.1 grade against the run over the course of the season ranks fourth among NFL edge defenders.

DL Solomon Thomas played 14 of his 29 snaps along the interior of the defensive line. He did, however, struggle with an overall Pro Football Focus grade of 45.4 while registering a quarterback hit.

DL Ronald Blair sacked Wilson for a loss of 16 yards, extending his single-season career high to 4.5 sacks. He now has 9.5 sacks in his career.

Key Team Statistics

The 49ers offense accumulated 452 total yards of offense compared to the Seahawks' 331. It had 386 in the air compared to Seattle's 163.

The Seahawks managed 168 rushing yards compared to the 49ers' 66.

The 49ers won the time-of-possession holding onto the football for 32:30.

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