No San Francisco 49ers wide receiver has more than 225 receiving yards this season. Second-year Rams receiver Cooper Kupp has 30 receptions for 438 yards with five touchdowns, which ranks him No. 3 among Los Angeles receivers in receiving yards.

The 49ers won't have to worry about planning for Kupp, according to Rams reporter Myles Simmons. Rams head coach Sean McVay said on Wednesday that the receiver is likely ruled out of Sunday afternoon's matchup at Levi's Stadium after suffering an MCL sprain during the team's Week 6 win over the Denver Broncos.

Kupp tried to return in the second half after being carted off the field but was very limited. He did not have a catch in the game. The Rams could rely more on second-year receiver Josh Reynolds in Kupp's absence.

The Rams made Kupp a third-round draft pick out of Eastern Washington in 2017. Kupp's five receiving touchdowns lead the team, and only four NFL receivers have more this season.