The 49ers are without tight end George Kittle on offense and without cornerback Richard Sherman and pass rusher Dee Ford on defense.
The good news is that newly-signed veteran wide receiver Mohamed Sanu and rookie receiver Brandon Aiyuk are active. A hamstring injury forced the rookie to miss Week 1.
San Francisco (0-1) currently leads New York (0-1) 7-0 at MetLife Stadium.
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