One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.
49ers rookie RB set to make NFL debut in huge game vs. Colts
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These 7 49ers players are inactive vs. Colts
By David Bonilla
Dec 22, 2025
The San Francisco 49ers have released the list of inactive players for their Week 16 matchup against the Indianapolis Colts. These seven players will not suit up for the game.
Inactives:
DL Robert Beal
DL Kevin Givens
CB Renardo Green (neck)
RB Isaac Guerendo
CB Chase...
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