The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN now.
How to watch Colts-49ers ‘Monday Night Football’ on ESPN
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49ers vs. Colts in Week 16: How to watch, stream, and listen, plus odds
49ers vs. Colts in Week 16: How to watch, stream, and listen, plus odds
By David Bonilla
Dec 17, 2025
The San Francisco 49ers head to Indianapolis for their final road trip of the regular season, taking on the Indianapolis Colts at Lucas Oil Stadium on ESPN's Monday Night Football. This matchup marks the 46th all-time meeting between the two teams, with the Colts leading the...
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