Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.
Ways to Watch and Listen: 49ers vs. Colts | Week 16 ‘Monday Night Football’
Published Dec 19, 2025 at 8:20 AM
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49ers vs. Colts in Week 16: How to watch, stream, and listen, plus odds
By David Bonilla
Dec 17, 2025
The San Francisco 49ers head to Indianapolis for their final road trip of the regular season, taking on the Indianapolis Colts at Lucas Oil Stadium on ESPN's Monday Night Football. This matchup marks the 46th all-time meeting between the two teams, with the Colts leading the...
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