Here's everything you need to know when the San Francisco 49ers play the Indianapolis Colts Week 16 of the 2025 NFL season.
49ers vs. Colts preview | Week 16
The above videos are auto-populated by an affiliate.
Follow us on:
The above link leads to an external page. 49ers Webzone has no control over its contents.
Read Next
Kyle Shanahan previews 49ers-Colts Week 16 matchup
Kyle Shanahan previews 49ers-Colts Week 16 matchup
By Site Staff
8 hrs
San Francisco 49ers head coach Kyle Shanahan addressed reporters ahead of Thursday's practice as the team gears up for its Week 16 matchup against the Indianapolis Colts. Here's everything he said.
Transcript provided by the San Francisco 49ers Communications staff.
Opening...
49ers practice and media schedule ahead of Week 16 matchup vs. Colts
49ers practice and media schedule ahead of Week 16 matchup vs. Colts
By Site Staff
Dec 16
The San Francisco 49ers will hold three full practices this week as they prepare for their Week 16 matchup against the Indianapolis Colts.
Head coach Kyle Shanahan, defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterback Brock Purdy are scheduled...
49ers vs. Colts in Week 16: How to watch, stream, and listen, plus odds
49ers vs. Colts in Week 16: How to watch, stream, and listen, plus odds
By David Bonilla
Dec 17
The San Francisco 49ers head to Indianapolis for their final road trip of the regular season, taking on the Indianapolis Colts at Lucas Oil Stadium on ESPN's Monday Night Football. This matchup marks the 46th all-time meeting between the two teams, with the Colts leading the...
49ers vs. Colts: Philip Rivers officially named starter in Week 16 clash
49ers vs. Colts: Philip Rivers officially named starter in Week 16 clash
By David Bonilla
Dec 15
The San Francisco 49ers are headed to Indianapolis for a Week 16 matchup against the Colts, and they now officially know who they'll be facing under center. While it was expected that quarterback Philip Rivers would make his second consecutive start after coming out of...
Latest
- Seahawks beat Rams in thriller: What the NFC West shift means for the 49ers
- Why the 49ers can't underestimate Philip Rivers in clash with Colts
- 49ers vs. Colts injury report: 6 players miss practice ahead of MNF clash
- Kyle Shanahan: Brandon Aiyuk has been 'extremely distant' since injury
- 49ers mailbag: What's up with Jordan Elliott's knee? Can SF stop Jonathan Taylor? What's on the 49ers' list for Santa?
Trending News
-
49ers Webzone • Dec 17
-
49ers Webzone • Dec 17
-
49ers Webzone • 13 hrs
-
49ers Webzone • Dec 17
-
49ers Webzone • 9 hrs
-
49ers Webzone • 7 hrs