NFL.com breaks down the playoff-clinching scenarios for Week 16 of the 2025 NFL season.
Playoff-clinching scenarios for Week 16 of 2025 NFL season
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49ers playoff scenarios: How San Francisco can clinch a berth in Week 16
By David Bonilla
Dec 16, 2025
The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their winning streak to five games as they push toward a return to the NFL postseason.
With a victory on Monday night at Lucas Oil Stadium, the 49ers would...
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