SANTA CLARA — The 49ers began their preparation for Sunday’s game against the Cleveland Browns with another defensive injury. Before heading out to the practice field, coach Kyle Shanahan said Sam Okuayinonu suffered a high ankle sprain in the 49ers’ Monday Night win over the Carolina Panthers. The defensive lineman will miss multiple weeks. Linebacker Tatum Bethune will sit out another week due to a high ankle sprain, along with kicker Eddy Pineiro, who is recovering from a hamstring injury. Linebacker Luke Gifford was limited during practice again with a hip and calf injury, but the 49ers got good news regarding defensive lineman Robert Beal, who returned to practice after clearing the NFL’s concussion protocol. Beal was a full participant in practice on Wednesday.Shanahan announced that the 49ers won’t open the practice window for any of their injured players this week — including receivers Brandon Aiyuk and Jacob Cowing, and defensive lineman Yetur Gross-Matos. “He’s coming along,” Shanahan said of Gross-Matos. “It’s been a tough year for him, missing all of training camp with his knee, and...
49ers lose another defensive lineman for multiple weeks due to ankle injury
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Key 49ers pass rusher expected to miss multiple weeks
By David Bonilla
Nov 26, 2025
The San Francisco 49ers got a win over the Carolina Panthers on Monday night, but the victory came with a setback. Defensive end Sam Okuayinonu left the game with an ankle injury and did not return. By Wednesday, the team provided an update on his status.
Head coach Kyle...
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